466 papers
Using population-genetic models, this study demonstrates that even weak sexual antagonism dramatically accelerates the evolution of recombination suppression on sex chromosomes compared to neutrality, with mating systems and the genomic origin of suppressors (heterogametic vs. homogametic) critically shaping the rate and direction of this evolutionary process in both XY and ZW systems.
This study demonstrates that in the social pine sawfly *Neodiprion sertifer*, collective defense against predation provides both direct and indirect (kin-selected) survival benefits, with individuals strategically modulating their contributions based on group size, sex ratio, and kinship to balance cooperation against the risk of exploitation.
This study introduces the Primate Genome-Phenome Archive (PGA), a comprehensive map linking protein-coding genomic variations to 263 complex traits across 224 primate species, thereby identifying thousands of gene-trait associations and lineage-specific adaptations through macroevolutionary analysis.
By leveraging the self-fertilizing mangrove rivulus (*Kryptolebias marmoratus*) to eliminate genetic variation, this study demonstrates that DNA methylation levels at 40 specific CpG sites predict chronological age with high accuracy, establishing a powerful model for isolating epigenetic aging from genetic effects.
This study reveals that the elephant shark (*Callorhynchus milii*) possesses three novel estrogen-responsive ER genes alongside an ER{beta} ortholog, demonstrating that despite the discovery of additional ER variants, the transcriptional activation of these receptors by estrogens remains substantially conserved with humans over 425 million years of evolution.
By analyzing nearly 25,000 *Pseudomonas aeruginosa* isolates from bronchiectasis patients, this study reveals that treatment-induced antibiotic resistance arises through diverse ecological and evolutionary mechanisms, including the predominance of pre-existing resistance, selective sweeps of costly mutations, and oscillating dynamics driven by trade-offs between subpopulations.
This paper introduces HapNet, an open-source Python package that automates the construction, visualization, and statistical summarization of population-aware haplotype networks from aligned FASTA files, offering a reproducible and scriptable alternative to existing interactive graphical tools.
This paper extends coalescent theory to account for population subdivision and migration by conditioning on specific population pedigrees, revealing that traditional models fail to capture significant pedigree effects in most scenarios except for the well-known structured-coalescent model, with a notable exception involving intermittent gene flow.
This study employs a stochastic spatial model and global sensitivity analysis to evaluate how organism dispersal and payload fitness costs influence the probability of failure and spatial confinement of gene drives, revealing significant variability in drive performance that informs their suitability for specific applications.
This study identifies and characterizes a conserved allatostatin C neuropeptide system in the octopus *Octopus vulgaris*, revealing a single peptide that differentially activates two distinct receptors with broad tissue distribution, suggesting a critical role in sensory processing and nociception with significant implications for cephalopod welfare.
This study demonstrates that environmental stress, specifically a high-sugar diet, increases gene expression variability across the transcriptome while simultaneously revealing a distinct, evolutionarily constrained genetic architecture (veQTL) that regulates this variability, particularly in key developmental pathways.
This study concludes that the Louisiana black bear's previously recognized subspecific status is unsupported because its high genetic differentiation stems primarily from historical population bottlenecks and drift rather than distinct adaptive evolution, suggesting conservation efforts should prioritize maintaining genetic diversity over subspecies recognition.
This study demonstrates that despite habitat degradation altering pollinator interactions, male-biased sexual selection persists in the dioecious plant *Silene dioica*, with anthropogenic environments specifically intensifying selection on male floral traits while maintaining consistent selection on female fertility-related traits.
By combining theoretical modeling with genomic data from 196 plant species, this study demonstrates that rapid speciation in small populations is a signature of non-ecological processes, thereby challenging the prevailing view that ecological speciation is the primary driver of biodiversity.
By integrating genomic and ecological modeling, this study reveals that the isolated Alpine subspecies of the Spanish Moon Moth faces an urgent extinction risk due to critically low genetic diversity and a projected major contraction of its suitable habitat by 2050.
This study reveals that coordinated adaptations in neural progenitor cells, which reduce their capacity and alter early dynamics, drive the evolutionary downscaling of the neocortex in marmosets compared to the ancestral gyrencephalic primate condition.
This study demonstrates that independently cold-adapted PACMAD grasses exhibit a constrained, conserved protein-level response to freezing, particularly through the retention and structural optimization of LEA3 proteins, suggesting that functional freezing tolerance relies on ancestral protective mechanisms rather than lineage-specific innovations.
This study utilizes ancient metagenomic analysis of dental calculus from Pleistocene and modern reindeer to reconstruct their oral and digestive microbiomes and diets, revealing both long-term continuity in rumen adaptations and spatio-temporal shifts in microbial and dietary profiles driven by ecological differences between ancient France and contemporary Scandinavia.
This study investigates positive selection in outer kinetochore and condensin proteins across diverse metazoan groups, finding sporadic signatures of selection in parasitic wasps, ray-finned fishes, and primates, but none in the asexual Amazon molly, which is exempt from centromere drive.
This study presents high-quality assemblies of germline-restricted chromosomes (GRCs) in four passerine birds, revealing that while these essential chromosomes retain a few ancestral genes, they undergo rapid, species-specific expansion of repetitive sequences and extensive rearrangements driven by programmed DNA elimination, creating a paradox of stable function amidst extraordinary structural dynamism.